Jak3 Antibody Summary
Peptide with the sequence AHPEGKHHSLSFS from the C terminus of the proteinSequence according to the Entrez Gene accession number NP_000206
Janus kinase 3 (JAK3) is a protein tyrosine kinasethat functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominately expressed in immune cells and transduces signals in response to activation ny tyrosine phosphorylation of cytokine receptors
IgG
Polyclonal
Goat
JAK3
IgG purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
Applications/Dilutions
- Western Blot
Reactivity Notes
Human.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
TBS
0.02% Sodium Azide
0.5 mg/ml
IgG purified
Alternate Names for Jak3 Antibody
- EC 2.7.10
- Jak3
- JAK3_HUMAN
- JAK-3EC 2.7.10.2
- JAKL
- JAKLtyrosine-protein kinase JAK3
- Janus kinase 3Leukocyte janus kinase
- LJAK
- L-JAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)
Background
JAK3 (Janus or Just Another Kinase 3) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a variety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues as well as perhaps one or more serine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon stimulated genes. JAK3 has been found predominantly in hematopoietic cells. Recently, it has also been located in normal and transformed human cell types. Some studies have suggested that JAK3 along with tyrosine kinase (Tyk2) are capable of performing the role of JAK2 if they were positioned correctly within the IFN gamma complex.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.