IL-21 Antibody Summary
Synthetic peptide: CDSYEKKPPKEFLERFKSLLQKMIHQHLS, corresponding to C terminal amino acids 118-146 of Human IL21.
Secreted
Peptide sequence is < 50 % identical to other interleukins in this region and is therefore not expected to cross-react.
IgG
Polyclonal
Rabbit
IL21
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
Applications/Dilutions
- ELISA
- Immunocytochemistry/Immunofluorescence 1:500
Reactivity Notes
Cross-reacts with Human. Expected to cross-react with Mouse (86% identity with immunogen), Cow (89% identity with immunogen), Dog (89% identity with immunogen) and Pig (89% identity with immunogen) due to sequence homology.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
10mM KHPO4, 0.14M NaCl and 1.0 mg/ml BSA
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for IL-21 Antibody
- IL21
- IL-21
- IL-21Za11interleukin-21
- interleukin 21
- interleukin-21 isoform
Background
A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.