IL-1 beta/IL-1F2 Antibody (1027B) [Phycoerythrin] Summary

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

catabolin
IL1 beta
IL-1 beta
IL-1
IL1B
IL-1b
IL1-BETA
IL-1F2
IL1F2IL-1 beta
interleukin 1, beta
interleukin-1 beta
preinterleukin 1 beta
pro-interleukin-1-beta

IL-1 is a common name for two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) sequence identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and may exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R Accessory Protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The human IL-1 beta cDNA encodes a 269 aa precursor that contains a 116 aa propeptide which is cleaved intracellularly by the cysteine protease IL-1 beta -converting Enzyme (Caspase-1/ICE) to generate an active cytokine (5-7). The 17 kDa mature human IL-1 beta shares 96% aa sequence identity with rhesus macaque, and 67-78% aa sequence identity with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.