IL-13 Antibody (32116.11) [DyLight 488] Summary

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

ALRHMGC116789
BHR1interleukin-13
IL13
IL-13
IL-13MGC116788
interleukin 13
MGC116786
NC30
P600

Human IL-13 was originally identified by differential screening of an anti-CD28 activated human peripheral blood mononuclear cell cDNA library as an induction-specific novel cytokine. It was also isolated from cDNA libraries of human T cell clones using the murine IL-13 (P600) cDNA as a probe.2 Human IL-13, a pleiotropic cytokine, is produced by activated Th0, Th1-like, Th2-like, and CD8 T cells.1 The gene for human IL-13 maps to chromosome 5 and is closely linked to the genes for IL-3, IL-4, IL-5, and GM-CSF.3 IL-13 inhibits proinflammatory cytokine production and stimulates antibody production.1 It induces proliferation in the human pre-myeloid cell line TF-1. IL-13 has multiple effects on the differentiation and functions of monocytes and macrophages. It suppresses cytotoxic functions and induces changes in the morphology of human monocytes and in the phenotype of human monocytes and B cells by upregulating MHC class II expression.4 IL-13 will also decrease the production of nitric oxide by activated murine macrophages, leading to impaired parasiticidal activity.5

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.