IGF-II Antibody Summary
Purified recombinant mouse IGF2 protein
Secreted protein
Detects a band at approximately 20kDa. Based on ELISA, this has a 25% cross-reactivity to human IGF2.
IgG
Polyclonal
Goat
IGF2
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS and 5% Trehalose
No Preservative
0.1 mg/ml
Immunogen affinity purified
Alternate Names for IGF-II Antibody
- C11orf43
- chromosome 11 open reading frame 43
- FLJ22066
- FLJ44734
- IGF2
- IGF-2
- IGFII
- IGF-II
- insulin-like growth factor 2 (somatomedin A)
- insulin-like growth factor II
- insulin-like growth factor type 2
- MSA
- PP9974
- somatomedin-A
Background
Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share approx imately 70% amino acid sequence identity. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular mass of approximately 7.4 kDa. Mouse and human IGF-II share 91% sequence identity. Insulin-like growth factor II has autocrine, paracrine, and endocrine functions. It is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney cells, and MCF-7 human breast carcinoma cells.2
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets : MAPK_Compound_Library inhibitors