ICEBERG Antibody Summary
Peptide with the sequence EEDPQLASKMGLH from the C terminus of the protein.Sequence according to the Entrez Gene accession number NP 067546
ICEBERG
IgG
Polyclonal
Goat
CARD18
IgG purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
Applications/Dilutions
- Western Blot 1:100-1:2000
Reactivity Notes
Human
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
TBS
0.02% Sodium Azide
0.5 mg/ml
IgG purified
Alternate Names for ICEBERG Antibody
- caspase recruitment domain family, member 18
- Caspase-1 inhibitor Iceberg
- ICEBERG caspase-1 inhibitor
- ICEBERGcaspase recruitment domain-containing protein 18
- pseudo-ICE
- UNQ5804
Background
ICEBERG consists essentially only of 1 CARD domain and is an inhibitor of pro-caspase 1 activation. It inhibits generation of IL-1b by interacting with caspase-1 and preventing association with RIP 2. ICEBERG functions as a competitive antagonist of RIP 2/pro-caspase 1 interactions and inhibits caspase 1-dependent pro-L-1b secretion in mononuclear cells. ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.