HLA G Antibody (G233) Summary
HLA-A2.1/human beta2-microglobulin double transgenic mice were immunized with murine L cells transfected with both human beta2-microglobulin and HLA-G.
This antibody (clone G233) recognizes several isoforms of HLA-G expressed in all populations of extravillous trophoblast (cell columns, interstitial trophoblast, endovascular trophoblast, placental bed giant cells). HLA-G belongs to the nonclassical MHC Class I molecules (MHC Class Ib). The antibody has been found not to cross-react with any other MHC Class I antigens (HLA-A, -B, -C, -E, -F).
IgG2a
Monoclonal
Mouse
HLA-G
Protein A purified
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Applications/Dilutions
- ELISA 1:2000
- Flow Cytometry 5 – 10 ug/ml
- Immunoprecipitation 1:50
- CyTOF-ready
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4)
15mM Sodium Azide
1.0 mg/ml
Protein A purified
Alternate Names for HLA G Antibody (G233)
- b2 microglobulin
- HLA class I histocompatibility antigen, alpha chain G
- HLA class I molecule
- HLA G antigen
- HLA G
- HLA-6.0
- HLA-G histocompatibility antigen, class I, G
- HLAG
- HLA-G
- major histocompatibility complex, class I, G
- MHC Class I Antigen G
- MHC-G
Background
HLA G belongs to the HLA class I heavy chain paralogues. It is a heterodimer consisting of a heavy chain (with a1, a2, a3 domains) and a light chain (beta 2 microglobulin). Alternate splicing provides both soluble and membrane bound forms of HLA G, with two soluble isoforms and four membrane bound isoforms. HLA G may be part of the fetal protection system and is expressed on fetal derived placental cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.