jns.2016.9

HHEX Antibody (2018B) [Alexa Fluor® 750] Summary

    Additional Information
    Recombinant Monoclonal Antibody.
    Immunogen
    E. coli-derived recombinant human HHEX
    Thr111-Gly270
    Accession # Q6UX06
    Specificity
    Detects human HHEX in direct ELISAs and Western blots.
    Isotype
    IgG
    Clonality
    Monoclonal
    Host
    Rabbit
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Applications/Dilutions

    Dilutions
        Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

    Storage
    Store the unopened product at 2 – 8 °C. Do not use past expiration date.
    Buffer
    Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HHEX Antibody (2018B) [Alexa Fluor® 750]

      hematopoietically expressed homeobox
      Hex
      HEXHMPH
      HHEX
      HMPH
      Homeobox protein HEX
      Homeobox protein PRH
      HOX11L-PEN
      PRH
      PRHhematopoietically-expressed homeobox protein HHEX
      PRHX
      PRHXhomeobox, hematopoietically expressed
      proline-rich homeodomain-containing transcription factor

Background

Hematopoietically-expressed homeobox protein (HHEX), also known as HEX, PRH and PRHX, is a 35-40 kDa member of the Homeobox family of transcription factors.  Family members are distinguished by an evolutionarily conserved DNA-binding homeodomain of 60 amino acids (aa), which for HHEX spans aa 137-196.  Human HHEX was initially isolated from hematopoietic tissue, and is present in several hematopoietic progenitors, where its expression is down-regulated during terminal cell differentiation.  HHEX is also expressed in the anterior visceral endoderm during early mouse development, and in some adult tissues of endodermal origin, including liver, lung and thyroid.  HHEX knockout in mice is embryonic lethal, with impaired forebrain, liver and thyroid development.  Human HHEX is 270 aa in length, and over aa 111-270, shares 93% and 95% identity with mouse and rat HHEX, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

14-Deazaneplanocin A (hydrochloride)

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