Gremlin 1 Antibody (3H4) Summary
GREM1 (NP_037504, 75 a.a. ~ 185 a.a) partial recombinant protein with GST tag.ESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
GREM1 – gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
IgG2a Kappa
Monoclonal
Mouse
GREM1
IgG purified
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Applications/Dilutions
- ELISA 1:100-1:2000
Antibody reactive against recombinant protein on ELISA. GST alone used as a negative control.
Reactivity Notes
Other species not tested.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
No Preservative
IgG purified
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Gremlin 1 Antibody (3H4)
- Cell proliferation-inducing gene 2 protein
- CKTSF1B1gremlin 1, cysteine knot superfamily, homolog
- Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
- DAN domain family member 2
- DAND2
- DAND2GREMLIN
- Down-regulated in Mos-transformed cells protein
- DRM
- DRMMGC126660
- GREM1
- gremlin 1
- gremlin 1-like protein
- Gremlin
- gremlin-1
- IHG-2
- Increased in high glucose protein 2
- increased in high glucose-2
- proliferation-inducing gene 2
Background
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.