Granzyme B Antibody (GB10) [Biotin] Summary
Purified human Granzyme B (GZMB)
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells
NB100-62617 recognises the serine protease Granzyme B(GZMB), which is expressed within the granules of cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell Granzyme B(GZMB) activates the cascade of caspases that finally results in cell death.
IgG1
Monoclonal
Mouse
GZMB
IgG purified
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Applications/Dilutions
- ELISA 1 ug/ml
- Sandwich ELISA
- Streptavidin Full length Protein
- Streptavidin Native Protein
- Streptavidin Native Protein
Reactivity Notes
Cross reacts with Chimpanzee, Monkey and Rhesus Monkey.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
TBS and 1.0% BSA
0.05% Sodium Azide
IgG purified
Notes
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for Granzyme B Antibody (GB10) [Biotin]
- CSPB
- CTLA-1
- CTSGL1
- Fragmentin-2
- Granzyme B
- Granzyme-2
- GRB
- GrzB
- GZMB
- HLP
- SECT
Background
Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets :　Cell_Counting_Kit-18 inhibitors