Glycophorin A Antibody (HIR2) [PE] Summary
Raji cells and spleen cells fused with NS1 cells
The antibody 1H4 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.
IgG2b
Monoclonal
Mouse
GYPA
Size Exclusion Chromatography
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Applications/Dilutions
- Flow Cytometry
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 ul reagent / 100 ul of whole blood or 10^6 cells in a suspension.
Packaging, Storage & Formulations
Store at 4C in the dark.
PBS and 0.2% (w/v) high grade BSA (protease free)
15mM Sodium Azide
Size Exclusion Chromatography
Alternate Names for Glycophorin A Antibody (HIR2) [PE]
- CD235a antigen
- CD235a
- glycophorin A (includes MN blood group)
- glycophorin A (MNS blood group)
- Glycophorin A
- glycophorin Erik
- glycophorin MiI
- glycophorin MiIII
- glycophorin MiV
- glycophorin MiX
- glycophorin SAT
- glycophorin Sta type C
- glycophorin-A
- GPA
- GPErik
- GpMiIII
- GPSAT
- GYPA
- HGpMiIII
- HGpMiV
- HGpMiX
- HGpMiXI
- HGpSta(C)
- Mi.V glycoprotein (24 AA)
- MN sialoglycoprotein
- MNS
- PAS-2
- recombinant glycophorin A-B Miltenberger-DR
Background
CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.