Galanin R1/GALR1 Antibody Summary
Synthetic 20 amino acid peptide from C-terminus of human GALR1.
C-terminal domain of human
Human GALR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
IgG
Polyclonal
Rabbit
GALR1
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 1:10-1:500
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Chimpanzee (95%), Orangutan (95%), Gibbon (95%), Monkey (89%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for Galanin R1/GALR1 Antibody
- GAL1
- Galanin R1
- galanin receptor 1
- galanin receptor type 1
- GalaninR1
- GALNR1
- GALNRGALNR1GAL1-R
- GALR1
- GALR-1
Background
GalR1 is a Galanin Receptor that mediates the effects of the peptide galanin in a wide variety of tissues. Unlike GalR2, the primary signaling mechanism of GalR1 is by inhibiting adenylate cyclase through Gi. GalR1 regulates the GnRH neuroendocrine axis with its expression in POMC neurons. Pathogens like E. coli can cause diarrhea by increasing expression of Galanin Receptor 1 in the epithelial cells lining the colon, resulting in increased secretion of colonocyte chloride and fluid. GalR1 has been reported in brain, spinal cord, small intestine, colon, and eye. ESTs have been isolated from nerve and fetal lung/testis/B-cell libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.