GPR74/NPFFR2 Antibody Summary
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human NPFFR2.
N-terminal extracellular domain of human
Human NPFFR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MFN2 (45%), MFN1 (45%).
Primate (95%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
NPFFR2
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 2.5 – 20 ug/ml
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (95%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for GPR74/NPFFR2 Antibody
- GPR74
- GPR74G protein-coupled receptor 74
- G-protein coupled receptor 74
- neuropeptide FF 2
- neuropeptide FF receptor 2
- Neuropeptide G-protein coupled receptor
- NPFF2
- NPFF2G-protein coupled receptor HLWAR77
- NPFFR2
- NPGPR
- NPGPRHLWAR77
Background
The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. The receptor is expressed in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, and in adipose tissue, suggesting other physiological and pathophysiological activities for FMRF-amide neuropeptides (Elshourbagy et al, 2000). Two isoforms are produced by alternative splicing. NPFF2 receptor has been reported to be expressed in various tissues, including brain, heart, intestine, placenta, prostate, spleen, adipose, spinal cord, colon, kidney, liver, lung, ovary, testis, pancreas, and thymus. ESTs have been isolated from fetal and placenta libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.