FADD Antibody (1A11) Summary
The immunogen is a peptide made to the amino acid region FADD
Human FADD
IgG1
Monoclonal
Mouse
FADD
Protein A or G purified
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Applications/Dilutions
- Western Blot 1:100-1:2000
- ELISA 1:3000-1:5000
- Immunoprecipitation 1:10-1:500
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
0.1M BBS (pH 8.2)
No Preservative
Protein A or G purified
Alternate Names for FADD Antibody (1A11)
- FADD
- Fas (TNFRSF6)-associated via death domain
- FAS-associated death domain protein
- FAS-associating death domain-containing protein
- GIG3
- Growth-inhibiting gene 3 protein
- Mediator of receptor induced toxicity
- mediator of receptor-induced toxicity
- MGC8528
- MORT1
- MORT1Fas-associating protein with death domain
- protein FADD
Background
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1 beta-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. (1-6)
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.