EDAR Antibody (RM0077-8L53) Summary
Mouse recombinant EC-domain of EDAR
This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant Extracellular Domain of EDAR.
IgG2
Monoclonal
Rat
EDAR
Protein G purified
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Applications/Dilutions
- Western Blot 1:500-1:1000
This antibody detects mouse EDRA in Western blotting and cross reacts with human EDAR.
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS
No Preservative
LYOPH
Protein G purified
Reconstitute with 0.2 ml sterilized PBS to a final concentration of 0.5 mg/ml.
Alternate Names for EDAR Antibody (RM0077-8L53)
- Anhidrotic ectodysplasin receptor 1
- DLED3
- Ectodermal dysplasia receptor
- ectodysplasin 1, anhidrotic receptor
- ectodysplasin A receptor
- Ectodysplasin-A receptor
- ED1R
- ED5
- EDA1R
- EDA3EDA-A1 receptor
- EDA-A1R
- EDAR
- FLJ94390
- HRM1
- mouse, homolog of
- tumor necrosis factor receptor superfamily member EDAR
Background
EDAR (Ectodysplasin A receptor) is a receptor for EDA isoform A1, but not for EDA isoform A2. It has a single transmembrane domain, and shows similarity to 2 separate domains of the tumor necrosis factor (TNF) receptor (TNFR) family. It mediates the activation of NF-kappa-B and JNK and may promote caspase independent cell death. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.