DOK2 Antibody – Pre-diluted Summary
Synthetic peptide corresponding to C-terminal of human DOK2 protein.
This product is specific for DOK2
IgG
Polyclonal
Rabbit
DOK2
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin Neat
IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Reactivity Notes
This product is specific for Human.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Prediluted antibody
No Preservative
Immunogen affinity purified
Alternate Names for DOK2 Antibody – Pre-diluted
- docking protein 2
- docking protein 2, 56kD
- docking protein 2, 56kDa
- Dok-2
- Downstream of tyrosine kinase 2
- p56(dok-2)
- p56DOK
- p56dok-2
Background
Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the DOK1 and DOK2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the DOK proteins serve as mediators of bcr-abl signaling. The role of DOK proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.