Cytokeratin 20 Antibody (Q2) Summary
BALB/C mice were immunized with partially purified human keratin 20 expressed in bacterial cells.
This antibody with a protein of 46 kD. Cytokeratin 20 is less acidic than other type I cytokeratins and is of interest due to its more restricted expression in tissue. Cytokeratin 20 is expressed primarily in gastric and intestinal epithelium, urothelium and Merkel- cells. Cytokeratin 20 is expressed in adenocarcinomas of colon, stomach, pancreas and the bile system.
IgG1
Monoclonal
Mouse
KRT20
Unpurified
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Applications/Dilutions
- Immunohistochemistry
- Immunohistochemistry-Paraffin 1:50-1:100
Reactivity Notes
Human
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Ascites
0.05% Sodium Azide
Unpurified
Alternate Names for Cytokeratin 20 Antibody (Q2)
- CD20
- CK20
- CK-20
- cytokeratin-20
- K20cytokeratin 20
- keratin 20
- keratin, type I cytoskeletal 20
- keratin-20
- KRT21
- MGC35423
- Protein IT
Background
Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant IF protein complement in an epithelial cell-specific manner. The protein encoded by this gene is a type I cytokeratin which consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. It maps to 17q21.2 region of human chromosome and has a molecular weight of 48553.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.