Collagen IV alpha 1 Antibody (COL-94) Summary
Human collagen type IV
Basement membrane
This antibody recognizes collagen type IV epitope located on the alpha1 and/or alpha 2 chains of human collagen type IV. This shows no cross reactivity with collagen types I, II, III, V, VI and VII and does not react with human vitronectin, fibronectin or chondroitin sulfate A, B and C.
IgG1
Monoclonal
Mouse
COL4A1
Unpurified
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Applications/Dilutions
- Immunohistochemistry
Reactivity Notes
Human.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Ascites
Sodium Azide
Unpurified
Alternate Names for Collagen IV alpha 1 Antibody (COL-94)
- alpha-1 chain
- arresten
- COL4A1 NC1 domain
- COL4A1
- collagen alpha-1(IV) chain
- Collagen IV alpha 1
- collagen IV, alpha-1 polypeptide
- collagen, type IV, alpha 1
- Collagen-4
- EC 3.4.23
- EC 6.3.1.2
Background
Collagen IV is a major constituent of the basement membranes along with laminins, proteoglycans and enactins. It is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. It can form insoluble fibers with high tensile strength. Collagen IV is useful in detecting the loss of parts of basement membranes in carcinomas.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.