Collagen I/II/III Antibody (NLI/22) Summary
Human placental collagen type 1
NB100-64521 reacts with collagens type I, II and III. It does not react with human collagen types IV, V or VI, human plasma proteins or albumin from various species.
IgM
Monoclonal
Mouse
COL1A1
IgM purified
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Applications/Dilutions
- ELISA 1:500-1:2000
- Immunocytochemistry/Immunofluorescence 1:5-1:20
Reactivity Notes
Human. Not yet tested in other species.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Mannitol, Dextran and Salts
No Preservative
LYOPH
IgM purified
Reconstitute with 1.0 ml sterilized distilled water to a final concentration of 0.1 mg/ml.
Alternate Names for Collagen I/II/III Antibody (NLI/22)
- Alpha-1 type I collagen
- collagen alpha 1 chain type I
- collagen alpha-1(I) chain
- collagen of skin, tendon and bone, alpha-1 chain
- collagen, type I, alpha 1
- OI4
- pro-alpha-1 collagen type 1
Background
Collagens are highly conserved throughout evolution and are characterised by an uninterrupted “Glycine X Y” triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.