Chorionic Gonadotropin beta Chain (HCG beta) Antibody (HCG-60) Summary
Human chorionic gonadotropin.
This antibody (clone HCG-60) reacts with beta-subunit of human chorionic gonadotropin (hCG), a 40 kDa hormone. hCG belongs to the glycoprotein hormone family together with lutropin (LH), follitropin (FSH) and thyrotropin (TSH). hCG is synthesised by trophoblastic cells of the placenta during pregnancy and stimulates the growth of corpus luteum. The HCG-60 antibody reacts with association constant 8.9 x 1010 l/mol. Following cross-reactivity (%) was determined by classic double-antibody RIA using unlabelled hormones: beta-hCG (73), alpha-hCG (1.6), hLH (1.2), hFSH (< 0.5), hTSH (< 0.5).
IgG1
Monoclonal
Mouse
CGB
Protein A purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
Applications/Dilutions
- ELISA 1:2000
- Immunocytochemistry/Immunofluorescence 1:10-1:2000
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4)
15mM Sodium Azide
0.5 mg/ml
Protein A purified
Alternate Names for Chorionic Gonadotropin beta Chain (HCG beta) Antibody (HCG-60)
- CGB
- CGB3
- CGB3choriogonadotropin subunit beta
- CGB5
- CGB7
- CGB8
- CG-Beta
- Choriogonadotropin Subunit Beta
- Chorionic gonadotrophin chain beta
- chorionic gonadotropin beta 3 subunit
- Chorionic Gonadotropin beta Chain
- chorionic gonadotropin beta subunit
- chorionic gonadotropin, beta polypeptide
- hCGB
Background
Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.