Cathepsin B Antibody [FITC] Summary
Native, from placenta
This antibody detects cathepsin B, a lysosomal cysteine protease which functions as both a endopeptidase and a carboxypeptidase. Together with cathepsins D and L, cathepsin B is one of the most abundant proteases in the lysosome, and participates in intracellular protein degradation.
IgG
Polyclonal
Sheep
CTSB
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
Applications/Dilutions
- ELISA 1:1000-1:10000
Reactivity Notes
Human.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.05% Sodium Azide
Protein G purified
Alternate Names for Cathepsin B Antibody [FITC]
- APP secretase
- APPS
- Cathepsin B
- Cathepsin B1
- CPSBamyloid precursor protein secretase
- CTSB
- cysteine protease
- EC 3.4.22
- EC 3.4.22.1
Background
Cathepsin B is a normal lysosomal proteinase that is expressed in all cells. It is a cysteine endoproteinase structurally and functionally related to the papain family of proteases. Cathepsin B is synthesized as an inactive 43 kDa pro enzyme which, by removal of a 62 amino acid propeptide, is activated to the single chain form of 31 kDa or the two chain form (25 and 5 kDa subunits). Matured Cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins at acidic and neutral pH. Endogenous inhibitors of cysteine proteases, the cystatins and stefins, may play a major role in regulating their activity. In tumor cells and in cells exposed to mitogens, cathepsin B displays altered cellular trafficking resulting in the secretion of the 43 kDa precursor. Elevated levels of Cathepsin B correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers. Cathepsin B has also been implicated in the pathogenesis of rhematoid arthritis, muscular dystrophy and tumor metastasis.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.