Caspase-8 Antibody (C502S) Summary
Synthetic peptide derived from the amino-terminal sequence of p10 of human caspase-8.
IgG1
Monoclonal
Rabbit
CASP8
Immunogen affinity purified
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Applications/Dilutions
- Western Blot
- Immunoprecipitation
Western blotting (0.5-4 ug/ml) and immunoprecipitation (10 ug/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
PBS, 1.0% BSA and 50% Glycerol
0.02% Thimerosal
Immunogen affinity purified
Alternate Names for Caspase-8 Antibody (C502S)
- AIS
- androgen receptor
- CASP8
- Caspase8
- Caspase-8
- DHTRTFM
- Dihydrotestosterone receptorHYSP1
- HUMARA
- Mch5
- NR3C4KD
- Nuclear receptor subfamily 3 group C member 4
- SMAX1SBMA
- spinal and bulbar muscular atrophy
Background
Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.