CXCR4 Antibody (44708, 44716, 44717, 12G5) [Biotin] Summary
1 vial each of clones 44708, 44716, 44717, and 12G5, biotinylated
Monoclonal
Mouse
CXCR4
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Applications/Dilutions
- Flow Cytometry
- Streptavidin Full length Protein
- Streptavidin Native Protein
- Streptavidin Native Protein
Packaging, Storage & Formulations
Store the unopened product at 2 – 8° C. Do not use past expiration date. Protect from light.
Supplied in a saline solution containing BSA and Sodium Azide.
Sodium Azide
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CXCR4 Antibody (44708, 44716, 44717, 12G5) [Biotin]
- CD184
- chemokine (C-X-C motif) receptor 4
- chemokine (C-X-C motif), receptor 4 (fusin)
- C-X-C chemokine receptor type 4
- CXCR4
- CXC-R4
- CXCR-4
- D2S201ESDF-1 receptor
- FB22
- Fusin
- HM89NPYRL
- HSY3RR
- LAP3
- LCR1
- LESTRCD184 antigen
- Leukocyte-derived seven transmembrane domain receptor
- leukocyte-derived seven-transmembrane-domain receptor
- lipopolysaccharide-associated protein 3
- neuropeptide Y receptor Y3
- NPY3RWHIM
- NPYR
- NPYY3R
- seven transmembrane helix receptor
- seven-transmembrane-segment receptor, spleen
- Stromal cell-derived factor 1 receptor
Background
CXCR4, also known as fusin or LESTR, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR4 is 352 amino acids (aa) in length with a predicted molecular weight of 40 kDa. The mouse and rat proteins share 91% aa sequence identity with the human protein. CXCR4 is the chemokine receptor for CXCL12. CXCR4 is a critical regulator of progenitor and stem cell mobilization and recruitment during development and during hematopoiesis. As such, antagonists of CXCR4 can be used to harvest hematopoietic stem/progenitor cells from bone marrow. Significantly, CXCR4 also acts as a co-receptor for HIV and mediates viral entry and infection of T cells. Studies on multiple tumor types implicate the CXCL12:CXCR4 axis in tumor metastasis and angiogenesis.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.