CXCR1/IL-8 RA Antibody (1122A) [Alexa Fluor® 488] Summary
Recombinant Monoclonal Antibody.
Mouse CXCR1/IL‑8 RA Peptide
Accession # Q810W6
Accession # Q810W6
Detects mouse CXCR1 transfectants but not CXCR2 transfectants by flow cytometry.
IgG
Monoclonal
Rabbit
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Applications/Dilutions
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 – 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CXCR1/IL-8 RA Antibody (1122A) [Alexa Fluor® 488]
- CD128
- CD181 antigen
- CD181
- CDw128aC-C
- chemokine (C-X-C motif) receptor 1
- CKR-1
- CMKAR1
- C-X-C chemokine receptor type 1
- CXCR1
- CXC-R1
- CXCR-1
- High affinity interleukin-8 receptor A
- IL-8 receptor type 1
- IL-8R A
- IL8R1
- IL8RA
- IL-8RA
- IL8RAC-C-CKR-1
- IL8RBA
- interleukin 8 receptor, alpha
- interleukin-8 receptor type 1
- interleukin-8 receptor type A
Background
CXCR1, also known as IL-8 RA and CD181, is an approximately 60 kDa 7TM glycoprotein that functions as a receptor for the chemokine CXCL8/IL-8. It is expressed on neutrophils, monocytes, CD8 T cells, FoxP3+ CD4 Treg cells, mast cells, neuronal and glial cells, vascular endothelial cells, and melanoma. CXCR1 forms homodimers and heterodimers with CXCR2/IL-8 RB. It can be cleaved from neutrophils in the lungs of cystic fibrosis patients to release fragments that promote CXCL8 production from airway epithelial cells. CXCR1 mediates neutrophil activation and chemotaxis to sites of inflammation as well as angiogenesis and melanoma invasiveness. Mouse CXCR1 shares 65% and 89% amino acid sequence identity with human and rat CXCR1, respectively.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.