CTLA-4 Antibody (1B8) [FITC] Summary
Extracellular portion of mouse CD152 fused to a mouse IgG2a.
This antibody recognises mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naive T-cells and is induced upon T-cell activation.
IgG
Monoclonal
Armenian Hamster
CTLA4
Protein A or G purified
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Applications/Dilutions
- Flow Cytometry <= 3 ug/10^6 cells
- In vitro assay
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS
0.05% Sodium Azide
Protein A or G purified
Notes
Protect conjugated forms from light.
Alternate Names for CTLA-4 Antibody (1B8) [FITC]
- CD
- CD152 antigen
- CD152
- CD152IDDM12
- CD28
- celiac disease 3
- CELIAC3
- CTLA4
- CTLA-4
- cytotoxic T-lymphocyte antigen 4
- cytotoxic T-lymphocyte protein 4
- Cytotoxic T-lymphocyte-associated antigen 4
- cytotoxic T-lymphocyte-associated protein 4
- cytotoxic T-lymphocyte-associated serine esterase-4
- GRD4
- GSE
- ICOS
- ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Background
The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (1-4) However CD152 is thought to be a negative regulator of T cell activation (1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer1, and is relatively conserved among humans, mice and chickens. (2)
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.