CRHR2/CRF2 Antibody Summary
Synthetic 18 amino acid peptide from 1st extracellular domain of human CRHR2.
Multi-pass membrane protein.
Human CRHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Porcine (94%), Bovine (94%), Rabbit (94%), Hamster (94%), Canine (94%), Monkey (94%), Primate (94%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
CRHR2
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 13 ug/ml
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Hamster (94%), Bovine (94%), Canien (94%), Rabbit (94%), Porcine (94%), Elephant (94%), Panda (94%), Mouse (89%), Rat (89%), Bat (89%), Equine (89%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for CRHR2/CRF2 Antibody
- corticotropin releasing hormone receptor 2
- corticotropin-releasing factor receptor 2
- Corticotropin-releasing hormone receptor 2
- CRF2
- CRF2R
- CRFR2
- CRF-R2
- CRF-R-2
- CRFR-2
- CRF-RB
- CRH2R
- CRHR2
- CRH-R2
- CRH-R-2
- HM-CRF
Background
CRHR2, a Corticotropin-Releasing Factor Receptor is a neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Mutations of the receptor reduce coping behaviors to stress and increase basal blood pressure. Three isoforms of CRHR2 are produced by alternative splicing. CRHR2 expression has been reported in various regions of the brain, as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal, and skeletal muscle. CRCH2alpha is the dominant isoform and is expressed widely. CRCH2beta is expressed in the hippocampus, septum, amygdala, heart, and skeletal muscle. CRHR2gamma is brain-specific. ESTs have been isolated from brain libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.