CD8 alpha Antibody (LT8) [PE] Summary
Normal human peripheral blood lymphocytes
Type I membrane protein (isoform 1) and secreted (isoform 2).
NB100-65399 recognises the alpha-chain of the CD8 antigen, a 32kD glycoprotein expressed by the cytotoxic-suppressor subset of T cells and weakly by NK cells. CD8 functions as a receptor for MHC Class I molecules.
IgG1
Monoclonal
Mouse
CD8A
Protein A or G purified
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Applications/Dilutions
- Flow Cytometry 1:10-1:1000
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reactivity Notes
Human. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4)
0.05% Sodium Azide
Protein A or G purified
Alternate Names for CD8 alpha Antibody (LT8) [PE]
- CD8 antigen, alpha polypeptide (p32)
- CD8
- CD8a antigen
- CD8a molecule
- Leu2 T-lymphocyte antigen
- Leu2
- MAL
- OKT8 T-cell antigen
- p32
- RPA-T8 antibody flow
- RPA-T8 Antibody
- RPA-T8 CD8
- RPA-T8 Clone
- RPA-T8 Flow
- T cell co-receptor
- T8 T-cell antigen
- T-cell antigen Leu2
- T-cell surface glycoprotein CD8 alpha chain
- T-lymphocyte differentiation antigen T8/Leu-2
Background
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.