CD44 Antibody (KM201) [Biotin] Summary
(C57BL/6 x DBA/2)F1 mouse bone marrow-derived stromal clone BMS2
Cell Membrane Marker
All isoforms of CD44/pgp-1 (Mr 80-95 kDa)
IgG1
Monoclonal
Rat
CD44
Protein A or G purified
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Applications/Dilutions
- Western Blot 1:100-1:2000
- Flow Cytometry <= 2 ug/10^6 cells
- Immunohistochemistry-Frozen 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
- Immunoprecipitation 1:10-1:500
- Immunocytochemistry
- Streptavidin Full length Protein
- Streptavidin Native Protein
- Streptavidin Native Protein
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS
0.05% Sodium Azide
Protein A or G purified
Notes
Protect conjugated forms from light.
Alternate Names for CD44 Antibody (KM201) [Biotin]
- CD44 antigen
- CD44 molecule (Indian blood group)
- CD44
- CD44R
- CDw44
- cell surface glycoprotein CD44
- chondroitin sulfate proteoglycan 8
- CSPG8
- ECMR-III
- epican
- Extracellular matrix receptor III
- GP90 lymphocyte homing/adhesion receptor
- HCAM
- HCELL
- hematopoietic cell E- and L-selectin ligand
- Heparan sulfate proteoglycan
- Hermes antigen
- homing function and Indian blood group system
- HUTCH-I
- Hyaluronate receptor
- IN
- LHR
- MC56
- MDU2
- MDU2CD44 antigen (homing function and Indian blood group system)
- MDU3
- MDU3CDW44
- MIC4
- MIC4MGC10468
- MUTCH-I
- Pgp1
- PGP-1
- PGP-I
- Phagocytic glycoprotein 1
- Phagocytic glycoprotein I
Background
CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.1-6
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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