CD44 Antibody (IM7.8.1R) [Alexa Fluor® 350] Summary
Recombinant Monoclonal Antibody.
Myeloid leukemia M1 cells induced with Dexamethasone
Detects human and mouse CD44 in flow cytometry.
IgG
Monoclonal
Rat
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Applications/Dilutions
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 – 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CD44 Antibody (IM7.8.1R) [Alexa Fluor® 350]
- CD44 antigen
- CD44 molecule (Indian blood group)
- CD44
- CD44R
- CDw44
- cell surface glycoprotein CD44
- chondroitin sulfate proteoglycan 8
- CSPG8
- ECMR-III
- epican
- Extracellular matrix receptor III
- GP90 lymphocyte homing/adhesion receptor
- HCAM
- HCELL
- hematopoietic cell E- and L-selectin ligand
- Heparan sulfate proteoglycan
- Hermes antigen
- homing function and Indian blood group system
- HUTCH-I
- Hyaluronate receptor
- IN
- LHR
- MC56
- MDU2
- MDU2CD44 antigen (homing function and Indian blood group system)
- MDU3
- MDU3CDW44
- MIC4
- MIC4MGC10468
- MUTCH-I
- Pgp1
- PGP-1
- PGP-I
- Phagocytic glycoprotein 1
- Phagocytic glycoprotein I
Background
CD44, also known asECMR-III, Hermes, Pgp1, Ly-24, GP90, or HUTCH, is a ubiquitously expressedprotein that is the major receptor for hyaluronic acid (HA). Mediates cell-celland cell-matrix interactions through its affinity for HA, and possibly also throughits affinity for other ligands such as osteopontin, collagens, and matrixmetalloproteinases (MMPs). Adhesion with HA plays an important role in cellmigration, tumor growth and progression. In cancer cells, may play an importantrole in invadopodia formation. Also involved in lymphocyte activation,recirculation and homing, and in hematopoiesis. Mouse CD44 has a 22 amino acid (aa) signalsequence, an extracellular domain (ECD) with a 100 aa hyaluronan-bindingdisulfide-stabilized link region and a 48-463 aa stem region, a 21 aatransmembrane domain, and a 72 aa cytoplasmic domain. CD44 exists as a largenumber of different isoforms due to alternative RNA splicing. Clone IM7.8.1 hasbeen reported to recognize all isoforms of CD44.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.