CD41/CD61 Antibody (CO.35E-4) Summary
Sheep leucocytes
NB100-63078 recognises ruminant CD41/CD61. Clone CO.35E4 has been reported to be suitable for use in Western blotting under reducing conditions bands of 100, 110 and 24kD are detected.
IgG1
Monoclonal
Mouse
ITGA2B
Tissue culture supernatant
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Applications/Dilutions
- ELISA 1:100-1:2000
- Flow Cytometry 1:10-1:1000
- Immunoprecipitation 1:10-1:500
Reactivity Notes
Sheep. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline
0.09% Sodium Azide
Tissue culture supernatant
Alternate Names for CD41/CD61 Antibody (CO.35E-4)
- CD41 antigen
- CD41
- CD41BHPA3
- GP2Bintegrin alpha-IIb
- GPalpha IIb
- GPIIb
- GTA
- integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
- integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
- ITGAB
- platelet fibrinogen receptor, alpha subunit
- Platelet membrane glycoprotein IIb
- platelet-specific antigen BAK
Background
Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.