CD40 Ligand/TNFSF5 Antibody (39H5) Summary
L cell transfected with CD40 Ligand
Cell membrane: single pass type II membrane protein. Processed form: secreted protein. Also exists as an extracellular soluble form.
NB100-65874 recognizes the murine CD154 cell surface antigen, a 39kD cell surface glycoprotein also known as CD40 ligand (CD40L). CD154 is expressed by activated CD4+ve T lymphocytes. This product is routinely tested in flow cytometry on mouse CD40L transfected L cells.
IgG
Monoclonal
Armenian Hamster
CD40LG
Protein G purified
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Applications/Dilutions
- Flow Cytometry 1:25-1:50
- Immunoprecipitation 1:10-1:500
Reactivity Notes
Reacts with Mouse.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4)
0.09% Sodium Azide
1.0 mg/ml
Protein G purified
Alternate Names for CD40 Ligand/TNFSF5 Antibody (39H5)
- CD154 antigen
- CD154
- CD40 antigen ligand
- CD40 Ligand
- CD40-L
- CD40LG
- CD40LIGM
- gp39
- hCD40L
- HIGM1
- T-B cell-activating molecule
- T-BAM
- T-cell antigen Gp39
- TNF-related activation protein
- TNFSF5
- TNFSF5IMD3
- TRAP
- TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
- tumor necrosis factor (ligand) superfamily member 5
- Tumor necrosis factor ligand superfamily member 5
Background
CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.