CD24 Antibody (30-F1) [PE] Summary

Protect conjugated forms from light.

CD 24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
CD24 antigen
CD24 molecule
CD24
CD24A
CD24Asignal transducer CD24
FLJ22950
FLJ43543
MGC75043
Small cell lung carcinoma cluster 4 antigen

CD24 is expressed in B cells until their terminal differentiation into plasma cells. (1) It has been used widely as a marker to fractionate different B-lineage differentiation stages. (10) CD24 has been found on a variety of other hematopoietic and neural cell types, and is now classified as a costimulatory molecule. (2-4) The CD24/HSA molecule is composed mostly of carbohydrate, with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse. (1, 3) The molecular mass is variable, ranging from38-70 kDa.3 CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins. (1-4) Studies with purified CD24 applied to latex beads have demonstrated a self-binding property, suggesting that the molecule is capable of promoting homotypic aggregation, binding and cell adhesion. (3) This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with anti-CD24 monoclonal antibody. (6) Recent studies of murine CD24 have assigned a role for CD24/HSA as a ligand for P-selectin, a calcium-dependent lectin. (7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.