CCR8 Antibody (1055C) [Alexa Fluor® 488] Summary

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CC chemokine receptor 8
C-C CKR-8
CC-chemokine receptor chemr1
CC-CKR-8
CCR8
CCR-8
CD198
CDw198 antigen
CDw198
chemokine (C-C motif) receptor 8
chemokine (C-C) receptor 8
chemokine (C-C) receptor-like 2
Chemokine receptor-like 1
ChemR1
CKRL1
CKR-L1
CKRL1MGC129966
CMKBR8MGC129973
CMKBRL2C-C chemokine receptor type 8
CY6
GPRCL1
GPRCY6
GPR-CY6
TER-1
TER1CC chemokine receptor CHEMR1

CCR8 (C-C chemokine Receptor 8; also known as CD198) is a 41-43 kDa member of the GPCR #1 family of transmembrane proteins. Mouse CCR8 is expressed on vascular smooth muscle cells, monocytes, eosinophils, peritoneal macrophages, thymocytes, CD8⁺ T cells, Langerhans cells and neurons. CCL1/TCA3 and vMIP-1 are known agonists for CCR8. Mouse CCR8 is a 7-transmembrane protein that is 353 amino acids (aa) in length. It contains a 33 aa N-terminal extracellular domain plus a 50 aa C-terminal cytoplasmic tail. In mouse, CCR8 is N- and possibly O-glycosylated, and known to be sulfated on Tyr14 and 15. The unusual nature of these posttranslational modifications may lead to anomalous migration in SDS-PAGE. There are two potential isoforms, one that shows a deletion of aa 103-163, and another that shows a Met substitution for aa 125-166. Over aa sequences 1-33 and 92-105 collectively, mouse CCR8 shares 64% and 85% aa identity with human and rat CCR8, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.