CARD14 Antibody (4B3) Summary
CARD14 (NP_077015, 905 a.a. ~ 1005 a.a) partial recombinant protein with GST tag.VQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR
CARD14 – caspase recruitment domain family, member 14
IgG2b Kappa
Monoclonal
Mouse
CARD14
IgG purified
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Applications/Dilutions
- ELISA
Antibody reactive against recombinant protein on ELISA. GST alone used as a negative control.
Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
No Preservative
IgG purified
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for CARD14 Antibody (4B3)
- bcl10-interacting maguk protein 2
- BIMP2
- CARD-containing MAGUK protein 2
- card-maguk protein 2
- Carma 2
- CARMA2CARD-containing MAGUK 2 protein
- caspase recruitment domain family, member 14
- caspase recruitment domain-containing protein 14
Background
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.