C-Reactive Protein/CRP Antibody (C1) Summary
Full length native protein (purified) (Human).
Secreted
does not react with Ca2+ depleted protein
IgG2b
Monoclonal
Mouse
CRP
Protein A purified
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Applications/Dilutions
- Western Blot 1:100-1:2000
- Immunoprecipitation 1:10-1:500
AP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 25 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Reactivity Notes
Cross-reacts with Human.Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4)
0.09% Sodium Azide
Protein A purified
Alternate Names for C-Reactive Protein/CRP Antibody (C1)
- C-Reactive Protein
- C-reactive protein, pentraxin-related
- CRP
- MGC88244
- pentraxin 1
- PTX1MGC149895
Background
C Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rupture.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets : p97 inhibitors