BST2 Antibody (44E9R) [Alexa Fluor® 700] Summary
Recombinant Monoclonal Antibody.
Recombinant extracellular domain of CD317
Detects mouse BST-2/Tetherin in flow cytometry.
IgG2a
Monoclonal
Rat
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Applications/Dilutions
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 – 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for BST2 Antibody (44E9R) [Alexa Fluor® 700]
- bone marrow stromal antigen 2
- bone marrow stromal cell antigen 2
- BST2
- BST-2
- CD317 antigen
- CD317
- HM1.24 Antigen
- NPC-A-7
- PDCA-1
- Tetherin
Background
BST-2, also known as Tetherin or PDCA1 and designated CD317, is a 30-35 kDa interferon-inducible protein that shows an unusual topology. The N-terminus is cytoplasmic, followed by a transmembrane segment, an extracellular loop, and a C-terminal GPI-linkage. BST-2 is expressed on bone marrow stromal cells and is upregulated in breast cancer and astrocytoma. It binds to ILT7 on plasmacytoid dendritic cells and inhibits proinflammatory TLR7 and TLR9 signaling. BST-2 inhibits the release of Kaposi sarcoma virus, HIV-1, and Lassa virus from infected cells, but this function is counteracted by viral proteins which directly bind and trigger the degradation of BST-2.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.