Attractin Antibody Summary
Synthetic 16 amino acid peptide from internal region of human ATRN / Attractin.
internal domain of human protein
Human ATRN / Attractin. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCTD19 (50%).
IgG
Polyclonal
Rabbit
ATRN
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 1:10 – 1:500
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Monkey (88%), Bovine (88%), Porcine (88%), Marmoset (81%), Rat (81%), Bat (81%), Hamster (81%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
0.7 mg/ml
Immunogen affinity purified
Alternate Names for Attractin Antibody
- ATRN
- Attractin
- DPPT-L
- KIAA0548
- Mahogany Protein
- MGC126754
- MGCA
Background
Attractin is a serum glycoprotein of 175 kDaand found in both membrane-bound and secreted forms as a result of alternative splicing. Both the secreted and membrane-bound forms of attractin may be involved in the development and maintenance of the central nervous system. Membrane-bound attractin is a co-receptor for Agouti, antagonist of melanocortin-1 receptor. Secreted attractin, expressed by activated T lymphocytes and modulates interactions between T cells and monocytes/macrophages, was examined as a potential marker of immune activity. Attractinmay be a component of a pathway for regulated protein turnover that alsoinvolves mahogunin, a wide-expressed E3 ubiquitinligase found at particularly high levels in the brain. Attractinwas considered as an extracellular target amenable for the development of obesity-regulating drugs, also.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.