5-HT2C Antibody Summary
Synthetic 16 amino acid peptide from C-terminus of human 5HT2C Receptor.
Human 5HT2C Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Monkey (94%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
HTR2C
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 3.8 ug/ml
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Chimpanzee (100%), Gorilla (94%), Orangutan (94%), Panda (94%), Gibbon (88%), Porcine (88%), Elephant (81%), Rabbit (81%), Equine (81%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for 5-HT2C Antibody
- 5-HT1C
- 5-HT-1C
- 5HT2C
- 5-HT2C
- 5-HT-2C
- 5-HT2C5-hydroxytryptamine receptor 1C
- 5-HTR2C
- 5-hydroxytryptamine (serotonin) receptor 2C
- 5-hydroxytryptamine receptor 2C
- HTR1C
- HTR2C
- serotonin 5-HT-2C receptor
- Serotonin Receptor 2C
Background
5-HT2C, a Serotonin Receptor previously termed 5-HT1C, activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. However, mCPP also has unpleasant side effects such as anxiety and nausea in humans. Most psychedelic drugs bind 5-HT2A and 5-HT2C receptors, and their hallucinogenicity correlates with binding affinity. Expression of the 5-HT2C receptor has been reported predominantly in brain, but also in spinal cord and lung. ESTs have been isolated from human, mouse, and rat brain libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.